resistance of shigella strains to extended-spectrum cephalosporins in isfahan province

نویسندگان

nasser mostafavi infectious diseases and tropical medicine research center, isfahan university of medical sciences, isfahan, iran.

moein bighamian child growth and development research center, research institute for primordial prevention of non communicable disease, isfa-han university of medical sciences, isfahan, iran.

sina mobasherizade nosocomial infections research center, isfahan university of medical sciences, isfahan, iran.

roya kelishadi child growth and development research center, research institute for primordial prevention of non communicable disease, isfa-han university of medical sciences, isfahan, iran.

چکیده

background: the aim of this study was to determine the serotypes and antimicrobial susceptibility of shigella spp. in isfahan, (iran) from 2010 to 2015.   methods: this retrospective study was conducted on shigella isolates in four tertiary care hospitals. the process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. the patients were categorized into three age groups of under 5, 5-15 and over 15 years.   results: among 45 isolates, s. sonnei (63.6%) was the predominant species, followed by s. flexneri (34.1%), and s. dysenteriae (2.3%). substantial resistance to ampicillin, trimethoprim- sulfamethoxazole, ceftriaxone, cefotaxime, and cefixime was observed. over 94% of the isolates were sensitive to ciprofloxacin. susceptibility of isolates was similar between all age groups.   conclusion: significant resistance to third generation cephalosporins precludes the use of these agents for empirical treatment of shigellosis in our population. ciprofloxacin is an appropriate option; however, susceptibility tests should be performed before prescription.

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Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۳۰، شماره ۱، صفحات ۹۳۲-۹۳۶

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